This presentation will describe the clinical history, purpose, and administration of hyperthermic intraperitoneal chemotherapy (HIPEC) and cytoreductive surgery (CRS) in various cancers involving the peritoneum. Common nutrition-impact symptoms, appropriate medical nutrition therapy, and metabolic needs will be thoroughly discussed in the preoperative, early postoperative, and long-term postoperative contexts. Participants will learn the importance of incorporating certain non-traditional elements into assessments and recommendations, and have the opportunity to apply these concepts in a case-study format.